Cardiac Troponin I

Background Information:

Cardiac Troponin I is a cardiac-specific inhibitory subunit of the troponin complex, a key regulatory protein in striated muscle contraction and relaxation. It is one of three subunits (alongside troponin T and troponin C) that make up the thin filament regulatory complex controlling calcium-dependent modulation of actomyosin ATPase activity in cardiac myocytes. Mutations in the TNNI3 gene have been associated with inherited cardiomyopathies such as familial hypertrophic cardiomyopathy type 7 and familial restrictive cardiomyopathy, reflecting its essential role in maintaining normal sarcomeric structure and function.

Target Class:

Ubiquitination-related

Family:

Troponin I

Sub Family:

Regulatory protein

Protein Name:

Cardiac Troponin I

Protein Aliases:

cTnI

Accession Number:

NM_000363.4

UniProt Number:

P19429

Gene Name:

TNNI3

Gene ID:

7137

Gene Aliases:

CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF

Target Species:

Human