Biological Information

Background Information:

UbcH5a is a class II E2 ubiquitin-conjugating enzyme that functions at the core of the ubiquitin–proteasome system (UPS). It mediates the transfer of ubiquitin from E1 (UBA1) to substrate proteins in conjunction with a wide range of E3 ubiquitin ligases. UbcH5a promotes degradation of tumor suppressors such as p53, and inhibiting this interaction is a potential strategy for restoring p53 activity in cancers.

Target Class:

Ubiquitination-related

Family:

ubiquitin-conjugating enzyme

Sub Family:

Transferase

Protein Name:

UbcH5a

Protein Aliases:

UbcH5; UBC4/5 homolog

Accession Number:

NM_003338.3

UniProt Number:

P51668

Gene Name:

UBE2D1

Gene ID:

7321

Gene Aliases:

SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Assay Measures:

ECL

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Neurological disorders/Inflammation