mTOR, active

Background Information:

N-Terminal FLAG-tagged, recombinant, full length human mTOR. mTOR (Mechanistic Target Of Rapamycin Kinase) belongs to the family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections.

Target Class:

Kinase

Family:

Phosphatidylinositol-3 kinase-related kinase (PIKK)

Sub Family:

Serine/threonine kinase (atypical)

Protein Name:

mTOR

Protein Aliases:

serine/threonine-protein kinase mTOR

Accession Number:

GenBank NM_004958.2

UniProt Number:

P42345

Gene Name:

MTOR

Gene ID:

2475

Gene Aliases:

SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1

Target Species:

Human