New GPCR White Paper

Assess GPCR Biased Signaling of Agonist

Using GPCR Functional Cell-based Assays

Explore the mechanistic basis and translational implications of biased agonism. Examine, via modern functional assays, the following:

  • Detection and quantification of signaling bias
  • Influence of bias signaling on the therapeutic profiles of existing and emerging drugs
  • Use of quantitative pharmacological tools such as transduction coefficients [log(τ/KA) or log(max/EC50)] to enable systematic comparison of biased agonists

This white paper was written by GPCR expert Terry Kenakin, Ph.D., Professor of Pharmacology, University of North Carolina School of Medicine, in collaboration with Eurofins DiscoverX.

Assess GPCR Biased Signaling of Agonist

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