Biological Information

Background Information:

The mammalian Abelson (Abl) family of non-receptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression. GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict with GenBank XM_136360. These are M982V, reported in GenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported in GenBank U40827. The residue coordinates in the native sequence have been given.

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

Arg

Protein Aliases:

Abelson-related gene

Accession Number:

XM_136360.1

UniProt Number:

Q4JIM5

Gene Name:

Abl2

Gene ID:

11352

Gene Aliases:

ARG

Target Species:

Mouse

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology