CHO-K1 GPR17 Gq Cell Line

Background Information:

The GPR17 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MDL 29,951) based activation of GPR17 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GPR17 , a naturally Gq coupled GPCR. Upon activation of GPR17 , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Class A Orphan

Sub Family:

Orphan and other 7TM

Coupling:

Gq

Protein Name:

GPR17

Protein Aliases:

G-protein coupled receptor 17|P2Y-like receptor|R12

Accession Number:

NM_005291

UniProt Number:

Q13304

Gene Name:

GPR17

Gene ID:

2840

Target Species:

Human

Cell Background:

CHO-K1