ChemiBRITE GPR120 Receptor Stable Cell Line

Background Information:

The ChemiBRITE GPR120 Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of FFAR4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR4 , a naturally Gq coupled GPCR. ChemiBRITE cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of FFAR4 , the resulting calcium activity can be assayed in either detection mode.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Free Fatty Acid

Sub Family:

Class A

Protein Name:

FFA4 (GPR120)

Protein Aliases:

G-protein coupled receptor 129|G-protein coupled receptor GT01|G-protein coupled receptor PGR4|Omega-3 fatty acid receptor 1

Accession Number:

BC101175.2

UniProt Number:

Q5NUL3

Gene Name:

FFAR4

Gene ID:

338557

Gene Aliases:

PGR4

Target Species:

Human

Cell Background:

HEK293