ChemiSCREEN™ CGRP1 Calcitonin Receptor-Like Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CGRP1 Calcitonin Receptor-Like Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. calcitonin) based activation of CALCRL - RAMP1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CALCRL alongside RAMP1 modifying protein and endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CALCRL , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Calcitonin

Sub Family:

Class B

Protein Name:

CLR

Protein Aliases:

Calcitonin receptor-like receptor

Accession Number:

AY389506

UniProt Number:

Q16602

Gene Name:

CALCRL

Gene ID:

10203

Gene Aliases:

CGRPR|CRLR

Target Species:

Human

Cell Background:

Chem-1