EphB2, active

Background Information:

Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. The primary function of EphB2 (Ephrin type-B receptor 2, DRT, EPTH3, ERK, HEK5) is to inactivate the Ras-MAPK pathway in a fashion that contributes to cytoskeletal reorganization and adhesion responses in neuronal growth cones. GenBank D31661. The recombinant protein is A848S and K918E with respect to this accession number. Both of these conflicts are reported in GenBank entries L36643, AF025304, NM_004442, NM_017449 and L41939.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EphB2

Protein Aliases:

Developmentally-regulated Eph-related tyrosine kinase|ELK-related tyrosine kinase|EPH tyrosine kinase 3|EPH-like kinase 5|EK5|hEK5|Renal carcinoma antigen NY-REN-47|Tyrosine-protein kinase TYRO5|Tyrosine-protein kinase receptor EPH-3 [Cleaved into: EphB2/CTF1; EphB2/CTF2]

Accession Number:

NM_004442.6; NM_017449.3

UniProt Number:

P29323

Gene Name:

EPHB2

Gene ID:

2048

Gene Aliases:

Hek5|Tyro5

Target Species:

Human