HEK 293 HTR2B Gq Cell Line

Background Information:

The HTR2B Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin) based activation of HTR2B GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses HTR2B , a naturally Gq coupled GPCR. Upon activation of HTR2B , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Serotonin

Sub Family:

Class A

Coupling:

Gq

Protein Name:

5-HT2B

Protein Aliases:

5-HT2B|Serotonin receptor 2B

Accession Number:

NM_000867.4

UniProt Number:

P41595

Gene Name:

HTR2B

Gene ID:

3357

Gene Aliases:

5-HT(2B)|5-HT2B

Target Species:

Human

Cell Background:

HEK293