MEKK3, active

Background Information:

MEKK3 is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In co-transfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. [provided by RefSeq, Jul 2008]

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

MEKK3

Protein Aliases:

MAP/ERK kinase kinase 3|MAPK/ERK kinase kinase 3

Accession Number:

NM_002401.3

UniProt Number:

Q99759

Gene Name:

MAP3K3

Gene ID:

4215

Gene Aliases:

MAPKKK3|MEKK3

Target Species:

Human