Biological Information

Background Information:

MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. GenBank NM_002446.2

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

MLK2

Protein Aliases:

MKN28 kinase|mixed lineage kinase 2|MKN28 derived nonreceptor_type serine/threonine kinase

Accession Number:

NM_002446.2

UniProt Number:

Q02779

Gene Name:

MAP3K10

Gene ID:

4294

Gene Aliases:

MST|MEKK10|MLK2

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

CNS/Addiction/Pain