Biological Information

Background Information:

MSK1 (mitogen- and stress-activated protein kinases-1, ribosomal protein S6 kinase, 90kDa, polypeptide 5) and MSK2 (mitogen- and stress-activated protein kinases-2, ribosomal protein S6 kinase, 90kDa, polypeptide 4) are activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK is activated by UV radiation, oxidative stress, and other cell-damaging stimuli. MSK may mediate the growth factor and stress-induced activation of CREB. GenBank AJ010119

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

MSK2

Protein Aliases:

90 kDa ribosomal protein S6 kinase 4|Nuclear mitogen- and stress-activated protein kinase 2|Ribosomal protein kinase B|RSKB

Accession Number:

AJ010119.1

UniProt Number:

O75676

Gene Name:

RPS6KA4

Gene ID:

8986

Gene Aliases:

RSK-B|MSK2

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology