Biological Information

Background Information:

Mer Protein is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). GenBank NM_006343. The recombinant protein contains the amino acid substitutions H628Q and R794A with reference to NM_006343. H628Q is reported in GenBank AA398845 and BG566419, R794A is reported in GenBank BG109051 and BX280572.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Mer

Protein Aliases:

Proto-oncogene c-Mer|Receptor tyrosine kinase MerTK

Accession Number:

NM_006343.2

UniProt Number:

Q12866

Gene Name:

MERTK

Gene ID:

10461

Gene Aliases:

mer|RP38|c-Eyk|Tyro12

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology