PASK, active

Background Information:

PASK kinase is a serine/threonine-protein kinase is involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. It probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

PASK

Protein Aliases:

PASKIN|hPASK

Accession Number:

NM_015148

UniProt Number:

Q96RG2

Gene Name:

PASK

Gene ID:

23178

Gene Aliases:

PASKIN|KIAA0135|STK37

Target Species:

Human