Biological Information

Background Information:

Protein kinase Cd (PKCd) is one of the major protein kinase C isoforms of a family of serine/threonine protein kinases. Breakdown of phosphatidylinositol leads to formation of diacylglycerol and inositol triphosphate, the former acting synergistically with Ca2+ to activate protein kinase C (PKC), resulting in translocation of the enzyme from cytosol to the membrane. Phosphorylation of proteins by PKC has been implicated as a pivotal regulatory element in signal transduction, cellular regulation, and with a high affinity to phorbol ester tumor promoters. GenBank L07861

Target Class:

Kinase

Family:

PKC

Sub Family:

Protein Ser/Thr

Protein Name:

PKCdelta

Protein Aliases:

Tyrosine-protein kinase PRKCD|nPKC-delta [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit|Sphingosine-dependent protein kinase-1|SDK1]

Accession Number:

NM_006254.3; NM_212539.1

UniProt Number:

Q05655

Gene Name:

PRKCD

Gene ID:

5580

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

CNS/Addiction/Pain