Biological Information

Background Information:

POLQ is a low-fidelity DNA polymerase with a helicase activity that plays a key role in microhomology-mediated end-joining (MMEJ), required to repair double-strand breaks in DNA during mitosis. POLQ is expressed at low levels in healthy cells but is often overexpressed in cancer cells. Recent studies suggest that many cancers become reliant on POLQ to repair DNA damage and blocking POLQ may prevent some cancer cells from repairing their DNA, leading to cancer cell death.

Target Class:

Helicase

Family:

Ski2-like

Sub Family:

DNA polymerase/helicase

Protein Aliases:

POLH

Accession Number:

NM_199420.4

UniProt Number:

O75417

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology