PTPN22, active

Background Information:

PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) is a member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. This protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. GenBank NM_015967

Target Class:

Phosphatase

Family:

Non-Receptor

Sub Family:

Protein Tyrosine

Protein Name:

PTPN22

Accession Number:

NM_015967.3

UniProt Number:

Q9Y2R2

Gene Name:

PTPN22

Gene ID:

26191

Gene Aliases:

Lyp|Lyp1|Lyp2

Target Species:

Human