PathHunter® GPR120L Total GPCR Internalization HEK 293 Cell Line

Background Information:

The PathHunter® GPR120L Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. free fatty acids) based internalization of GPR120L via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged GPR120L and a PK-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the GPR120L receptor to the early endosome leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Free Fatty Acid

Sub Family:

Class A

Protein Name:

FFA4 (GPR120)

Protein Aliases:

G-protein coupled receptor 129|G-protein coupled receptor GT01|G-protein coupled receptor PGR4|Omega-3 fatty acid receptor 1

Accession Number:

NM_181745

UniProt Number:

Q5NUL3

Gene Name:

FFAR4

Gene ID:

338557

Gene Aliases:

PGR4

Target Species:

Human

Cell Background:

HEK293