PathHunter® U2OS mBRS3 β-Arrestin Cell Pool

Background Information:

The PathHunter® mBRS3 Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. bombesin) based activation of mBRS3 GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mBRS3 and EA-tagged β-Arrestin-2. Activation of mBRS3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.

Target Class:

GPCR

Family:

Bombesin

Sub Family:

Class A

Protein Name:

BB3

Accession Number:

NM_009766.3

UniProt Number:

O54798

Gene Name:

Brs3

Gene ID:

12209

Gene Aliases:

BB3|BB3R|BBR3

Target Species:

Mouse

Cell Background:

U2OS