Plk1, active

Background Information:

Polo-like kinases (PLKs) are a family of serine/threonine kinases related to the polo gene product of Drosophila melanogaster, originally identified from a mitotic mutant that displayed abnormal spindle poles. PLKs play essential roles in several stages of mitosis and cytokinesis with a dynamic pattern of localization to centrosomes, kinetochores and central spindle structures during the cell cycle. PLK1 has been shown to be overexpressed in many human tumors, such as non-small cell lung cancer, squamous cell carcinomas of the head and neck, melanomas, oropharyngeal carcinomas, and ovarian and endometrial carcinomas. GenBank NM_005030

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

PLK1

Protein Aliases:

Polo-like kinase 1|PLK-1|Serine/threonine-protein kinase 13|STPK13

Accession Number:

NM_005030

UniProt Number:

P53350

Gene Name:

PLK1

Gene ID:

5347

Target Species:

Human