Ron, active

Background Information:

RON is a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Ron

Protein Aliases:

c-met-related tyrosine kinase

Accession Number:

NM_002447.1

UniProt Number:

Q04912

Gene Name:

MST1R

Gene ID:

4486

Gene Aliases:

CDw136|CD136|PTK8|RON

Target Species:

Human