ActRIIB, active

Background Information:

ActRIIB (Activin receptor type-2B) is a type II transmembrane serine/threonine kinase receptor that is involved in the signaling of members of the TGF-β superfamily of cytokines, including activin, myostatin, and growth and differentiation factor 11 (GDF11). ActRIIB signaling has been shown to inhibit muscle growth and promote muscle wasting through the activation of the Smad2/3 signaling pathway and the subsequent repression of muscle-specific genes. Research has suggested that targeting ActRIIB signaling may be a potential therapeutic strategy for the treatment of muscle wasting diseases, such as sarcopenia, cachexia, and muscular dystrophy. Several drugs targeting ActRIIB signaling, including the myostatin inhibitors and selective androgen receptor modulators (SARMs), are currently in clinical development as potential therapies for these conditions.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

ActR2B

Protein Aliases:

Activin receptor type IIB|ACTR-IIB

Accession Number:

NM_001106.3

UniProt Number:

Q13705

Gene Name:

ACVR2B

Gene ID:

93

Target Species:

Human