Biological Information

Background Information:

ALK or anaplastic lymphoma kinase (Ki-1) is a membrane-spanning tyrosine kinase receptor that is most closely related to leukocyte tyrosine kinase. No function has been ascribed for ALK; however, its restricted expression in neural tissue suggests that this receptor might play an important role in the normal development and function of the nervous system. Large-cell anaplastic lymphoma is a subtype of non-Hodgkin's lymphoma. Over half of these lymphomas have a chromosomal translocation t(2;5), that leads to the expression of a hybrid protein comprised of the nucleolar phosphoprotein nucleophosmin (NPM) and ALK. GenBank U62540

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

ALK

Protein Aliases:

Anaplastic lymphoma kinase|CD antigen CD246

Accession Number:

NM_004304.3

UniProt Number:

Q9UM73

Gene Name:

ALK

Gene ID:

238

Gene Aliases:

CD246

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology