ATM, active

Background Information:

ATM is a serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes.

Target Class:

Kinase

Family:

PIKK

Sub Family:

Atypical

Protein Name:

ATM

Protein Aliases:

TEL1, telomere maintenance 1, homolog (S. cerevisiae)

Accession Number:

NM_000051

UniProt Number:

Q13315

Gene Name:

ATM

Gene ID:

472

Gene Aliases:

TEL1|TELO1

Target Species:

Human