Biological Information

Background Information:

The cAMP Hunter™ rDRD1 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine, A68930) based activation of rDRD1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type rDRD1 , a naturally Gs coupled GPCR. Upon activation of rDRD1 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein.

Target Class:

GPCR

Family:

Dopamine

Sub Family:

Class A

Coupling:

Gs

Protein Name:

D1

Protein Aliases:

Dopamine D1 receptor

Accession Number:

NM_012546

UniProt Number:

P18901

Gene Name:

DRD1

Gene ID:

24316

Target Species:

Rat

Cell Background:

CHO-K1

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

cAMP Detection

Detection Method:

Chemiluminescence

Additional Information

Brand:

cAMP Hunter™