cAMP Hunter™ CHO-K1 RXFP1 Gs Cell Line

Background Information:

The cAMP Hunter™ RXFP1 (LGR7) Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. relaxin-2) based activation of RXFP1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type RXFP1 , a naturally Gs coupled GPCR. Upon activation of RXFP1 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Relaxin Family Peptide

Sub Family:

Class A

Coupling:

Gs

Protein Name:

RXFP1

Protein Aliases:

Relaxin family peptide receptor 1

Accession Number:

NM_021634.2

UniProt Number:

Q9HBX9

Gene Name:

RXFP1

Gene ID:

59350

Gene Aliases:

RXFPR1

Target Species:

Human

Cell Background:

CHO-K1