ChemiSCREEN™ alpha1A Adrenoceptor Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ α1A Adrenoceptor Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRA1A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADRA1A alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of ADRA1A , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Adrenoceptor

Sub Family:

Class A

Protein Name:

alpha1A

Protein Aliases:

Alpha-1A adrenoceptor|Alpha-1C adrenergic receptor|Alpha-adrenergic receptor 1c

Accession Number:

NM_000680

UniProt Number:

P35348

Gene Name:

ADRA1A

Gene ID:

148

Gene Aliases:

ADRA1L1|ADRA1C

Target Species:

Human

Cell Background:

Chem-1