ChemiSCREEN™ BB2 Bombesin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ BB2 Bombesin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bombesin) based activation of GRPR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GRPR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of GRPR , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Bombesin

Sub Family:

Class A

Protein Name:

BB2

Protein Aliases:

bombesin receptor 2

Accession Number:

NM_005314

UniProt Number:

P30550

Gene Name:

GRPR

Gene ID:

2925

Gene Aliases:

BB2|BB2R

Target Species:

Human

Cell Background:

Chem-1