ChemiSCREEN™ CCK1 Cholecystokinin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CCK1 Cholecystokinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. cholecystokinin) based activation of CCKAR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCKAR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCKAR , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Cholecystokinin

Sub Family:

Class A

Protein Name:

CCK1 (CCKA)

Protein Aliases:

CCK-AR|Cholecystokinin-1 receptor|CCK1-R

Accession Number:

NM_000730

UniProt Number:

P32238

Gene Name:

CCKAR

Gene ID:

886

Target Species:

Human

Cell Background:

Chem-1