ChemiSCREEN™ Y4 Neuropeptide Y Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ Y4 Neuropeptide Y Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. peptide YY) based activation of NPY4R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NPY4R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NPY4R , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Neuropeptide Y

Sub Family:

Class A

Protein Name:

Y4

Protein Aliases:

Pancreatic polypeptide receptor 1|PP1

Accession Number:

NM_005972

UniProt Number:

P50391

Gene Name:

NPY4R

Gene ID:

5540

Gene Aliases:

Y4|PP1

Target Species:

Human

Cell Background:

Chem-1