DOT1L

Background Information:

DOT1L (disruptor of telomeric silencing 1-like) is an epigenetic protein that functions as a histone methyltransferase. It is responsible for adding methyl groups to specific lysine residues on histones, leading to the formation of heterochromatin and repression of gene expression. DOT1L is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant DOT1L activity has been implicated in various diseases, including cancer, leukemia, and neurodevelopmental disorders. DOT1L inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.

Target Class:

Epigenetic

Family:

Histone Methyltransferase (HMT)

Sub Family:

Writer

Protein Name:

DOT1L

Protein Aliases:

histone methyltransferase DOT1L

Accession Number:

NM_032482.3

UniProt Number:

Q8TEK3

Gene Name:

DOT1L

Gene ID:

84444

Gene Aliases:

KIAA1814|DOT1|KMT4

Target Species:

Human