HIF-1-alpha

Background Information:

HIF-1-alpha is a transcription factor that serves as a central regulator of the cellular response to low oxygen tension (hypoxia). Under normal oxygen conditions, HIF-1-alpha is hydroxylated by prolyl hydroxylase domain enzymes and targeted for proteasomal degradation via recognition by the VHL E3 ubiquitin ligase complex. During hypoxia, hydroxylation is inhibited, allowing HIF-1-alpha to accumulate, translocate to the nucleus, and activate transcription of genes that promote angiogenesis, erythropoiesis, glucose metabolism, and cell survival. Overactivation of HIF-1-alpha supports tumor growth, angiogenesis, and metabolic reprogramming, making it a major oncogenic driver. Inhibitors that block HIF-1-alpha stability, dimerization, or transcriptional activity are under development as anticancer agents.

Target Class:

Ubiquitination-related

Family:

HIF

Sub Family:

Transcription factor

Protein Name:

HIF-1-alpha

Protein Aliases:

HIF1-alpha; bHLHe78

Accession Number:

NM_001530.3

UniProt Number:

Q16665

Gene Name:

HIF1A

Gene ID:

3091

Gene Aliases:

HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha

Target Species:

Human