Biological Information

Background Information:

LIM domain kinases 1 and 2 (LIMK1 and LIMK2) play a critical role in stimulus-induced remodeling of the actin cytoskeleton by linking signals from the Rho family GTPases. LIMKs specifically phosphorylate and inactivate cofilin, an actin-binding protein that stimulates depolymerization and severance of actin filaments, thereby regulating actin cytoskeletal reorganization. Inhibition of LIMK1 may be useful in the treatment of tumors, especially invasive breast and prostate cancer cells. GenBank NM_002314

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

LIMK1

Accession Number:

NM_002314.2

UniProt Number:

P53667

Gene Name:

LIMK1

Gene ID:

3984

Gene Aliases:

LIMK

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology