Biological Information

Background Information:

MDM2 is a RING-type E3 ubiquitin ligase that plays a central role in regulating the tumor suppressor protein p53. Under normal conditions, MDM2 binds directly to the transactivation domain of p53, inhibiting its transcriptional activity and mediating its ubiquitination and proteasomal degradation. This autoregulatory feedback loop ensures that p53 activity remains low in the absence of cellular stress. MDM2 overexpression or amplification is often seen in liposarcomas, leukemias, and some breast and lung cancers.

Target Class:

Ubiquitination-related

Family:

MDM2/MDM4

Sub Family:

E3 Ligase

Protein Name:

MDM2

Protein Aliases:

Mdm2; Hdm2

Accession Number:

AF527840.1

UniProt Number:

Q00987

Gene Name:

MDM2

Gene ID:

4193

Gene Aliases:

HDMX; LSKB; hdm2; ACTFS

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Enzymatic

Assay Measures:

ECL

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology