NUAK2, active

Background Information:

Stress-activated kinase NUAK2 involved in tolerance to glucose starvation. It induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway GenBank BC017306.2

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

Nuak2 (SNARK)

Protein Aliases:

SNF1/AMP activated protein kinase

Accession Number:

BC017306.2

UniProt Number:

Q9H093

Gene Name:

NUAK2

Gene ID:

81788

Gene Aliases:

SNARK|FLJ90349

Target Species:

Human