Biological Information

Background Information:

Parkin is an E3 ubiquitin ligase that operates within a multiprotein E3 ligase complex to catalyze the covalent attachment of ubiquitin to substrate proteins. It modifies targets through mono- and polyubiquitination, assembling Lys6-, Lys11-, Lys48-, and Lys63-linked ubiquitin chains depending on the cellular context. Parkin recognizes a wide range of substrates, including VDAC1, MFN1/2, RHOT1 (MIRO1), TOMM20, SYT11, BCL2, CCNE1, SNCAIP, USP30, and ZNF746 (PARIS), among others. Through these ubiquitination events, Parkin regulates protein turnover, mitochondrial homeostasis, autophagy, and neuronal survival. Loss-of-function mutations or deletions in parkin are one of the most common genetic causes of autosomal-recessive early-onset Parkinson's disease.

Target Class:

Ubiquitination-related

Family:

RBR

Sub Family:

E3 Ligase

Protein Name:

Parkin

Protein Aliases:

PARK2

Accession Number:

NM_004562.2

UniProt Number:

O60260

Gene Name:

PRKN

Gene ID:

5071

Gene Aliases:

PDJ; AR-JP; LPRS2; PARK2

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Assay Measures:

ECL

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Neurological disorders