PathHunter® NCI-H460 CDC25A Degradation Cell Line

Background Information:

The PathHunter® NCI-H460 CDC25A Degradation Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the cell cycle checkpoint pathway. This cell line enables detection of levels of CDC25a, allowing for assessment of CHK-1-activation-induced CDC25a degradation. This product uses EFC technology. The cell line included overexpresses CDC25a target protein fused to PL. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of CDC25a EFC signal is lost.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Phosphatase

Family:

Dual Specificity

Sub Family:

Protein Tyrosine

Protein Name:

CDC25A

Protein Aliases:

Cell division cycle 25A|Dual specificity phosphatase Cdc25A|MPIP1

Accession Number:

NM_001789.2

UniProt Number:

P30304

Gene Name:

CDC25A

Gene ID:

993

Target Species:

Human

Cell Background:

NCI-H460