PathHunter® U2OS EGFR/ErbB2 Dimerization Cell Line

Background Information:

The PathHunter® EGFR/ErbB2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. EGF) induced dimerization of EGFR/ErbB2 receptors. This product uses EFC technology. The cell line included overexpresses ErbB2 target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of EGFR/ErbB2 , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EGFR

Protein Aliases:

erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)|erb-b2 receptor tyrosine kinase 1

Accession Number:

NM_005228.3

UniProt Number:

P00533

Gene Name:

EGFR

Gene ID:

1956

Gene Aliases:

ERBB1

Target Species:

Human

Cell Background:

U2OS