PI3K-C2alpha

Background Information:

PI3K-C2α protein belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. GenBank BC113658

Target Class:

Kinase

Family:

PtdIns4P 3-Kinase

Sub Family:

Lipid

Protein Name:

PI3K-C2alpha

Accession Number:

NM_002645.2

UniProt Number:

O00443

Gene Name:

PIK3C2A

Gene ID:

5286

Gene Aliases:

PI3K-C2alpha

Target Species:

Human