Biological Information
Background Information:
The PrecisION™ Kir6.2/SUR2A membrane prep is a crude membrane prep with high levels of Kir6.2/SUR2A for use in studying binding affinity of drug candidates (small molecules or biologics) targeting ion channels. This membrane prep enables assessment of ligand binding affinity via detection of levels of radioactivity. It is derived from our proprietary stable recombinant cell lines to ensure high levels of Kir6.2/SUR2A surface expression. PrecisION™ membrane preps can be used to screen for ligand binding affinities at Kir6.2/SUR2A using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1mL of 2mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression.
Target Class:
Ion Channel
Family:
Potassium
Sub Family:
Voltage-Gated
Accession Number:
NM_000525.3/NM_005691.2
Target Species:
Human
Cell Background:
HEK293
Usage
Product Type:
Membrane Preparations
Application:
Drug Discovery & Development
Storage Conditions:
On receipt of material store at -80°C.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Binding
Additional Information
Brand:
PrecisION™