PRK1, active

Background Information:

N-terminal GST-tagged, recombinant, human PRK1, amino acids 498-end. PRK1 is a member of the serine/threonine protein kinase family. Involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Acts as a key coactivator of androgen receptor (AR)-dependent transcription. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus.

Target Class:

Kinase

Family:

AGC

Sub Family:

Serine/threonine kinase

Protein Name:

PKN1

Protein Aliases:

Protease-activated kinase 1|PAK-1|Protein kinase C-like 1|Protein kinase C-like PKN|Protein kinase PKN-alpha|Protein-kinase C-related kinase 1|Serine-threonine protein kinase N

Accession Number:

NM_002741.5

UniProt Number:

Q16512

Gene Name:

PKN1

Gene ID:

5585

Gene Aliases:

DBK|PRK1|PKN|MGC46204|PAK1

Target Species:

Human