Pyk2, active

Background Information:

Proline-rich tyrosine kinase 2 (PTK2B) (also called CAKb for cell adhesion kinase b, RAFTK for related adhesion focal tyrosine kinase, or CADTK for calcium-dependent tyrosine kinase) is a non-receptor tyrosine kinase structurally related to focal adhesion kinase (FAK). PTK2B interacts with Src family kinases and focal adhesion proteins such as p130Crk-associated substrate (p130Cas) and its homologue p105 human enhancer of filamentation 1 (HEF1). PTK2B is particularly enriched in pulmonary vascular endothelial cells and lung, a major organ site for tumor metastasis. Inhibitors of PTK2B may be useful in the treatment of lung cancer. GenBank S80542

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

PYK2

Protein Aliases:

Calcium-dependent tyrosine kinase|CADTK|Calcium-regulated non-receptor proline-rich tyrosine kinase|Cell adhesion kinase beta|CAK-beta|CAKB|Focal adhesion kinase 2|FADK 2|Proline-rich tyrosine kinase 2|Related adhesion focal tyrosine kinase|RAFTK

Accession Number:

NM_004103.3; NM_173174.1; NM_173175.1; NM_173176.1

UniProt Number:

Q14289

Gene Name:

PTK2B

Gene ID:

2185

Gene Aliases:

CAKB|PYK2|RAFTK|PTK|CADTK|FAK2

Target Species:

Human