Ready-to-Assay CCR8 Chemokine Receptor Frozen Cells

Background Information:

The Ready-to-Assay CCR8 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. CCL1) based activation of CCR8 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress CCR8 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CCR8 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CCR8

Protein Aliases:

CC-CKR-8|CCR-8|CC chemokine receptor CHEMR1|CMKBRL2|Chemokine receptor-like 1|CKR-L1|GPR-CY6|GPRCY6|TER1|CD antigen CDw198

Accession Number:

U45983

UniProt Number:

P51685

Gene Name:

CCR8

Gene ID:

1237

Gene Aliases:

CY6|TER1|CKR-L1|GPR-CY6|CDw198

Target Species:

Human

Cell Background:

Chem-1