SRPK2, active

Background Information:

Two SR Protein-specific Kinases, SRPK1 and SRPK2, have been shown to phosphorylate specifically the RS motifs of the SR family of splicing factors. Phosphorylation of an SR protein (ASF/SF2) by either SRPK1 or 2 enhanced its interaction with another RS domain-containing protein, and overexpression of either kinase induced specific redistribution of splicing factors in the nucleus. SRPK2 contains a proline-rich sequence at its NH2 terminus, the capacity to interact with a WW domain protein in vitro. Inhibition of SRPK2 may render male germ cell and other tumors insensitive to cisplatin. GenBank NM_182691

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

SRPK2

Protein Aliases:

SR protein kinase 2|serine/arginine-rich splicing factor kinase 2

Accession Number:

NM_182691.1; NM_182692.1

UniProt Number:

P78362

Gene Name:

SRPK2

Gene ID:

6733

Gene Aliases:

SFRSK2

Target Species:

Human