TAO3, active

Background Information:

TAO3 is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. In response to DNA damage, TAO3 is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. GenBank NM_016281. The recombinant protein contains the amino acid substitution N47S with reference to NM-016281. This mutation is reported in GenBank BC002756 and BC7007185

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

TAO3

Protein Aliases:

Cutaneous T-cell lymphoma-associated antigen HD-CL-09|CTCL-associated antigen HD-CL-09|Dendritic cell-derived protein kinase|JNK/SAPK-inhibitory kinase|Jun kinase-inhibitory kinase|Kinase from chicken homolog A|hKFC-A|Thousand and one amino acid protein 3

Accession Number:

NM_016281.3

UniProt Number:

Q9H2K8

Gene Name:

TAOK3

Gene ID:

51347

Gene Aliases:

JIK|DPK|MAP3K18

Target Species:

Human