TrkC, active

Background Information:

TrkC is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

TRKC

Protein Aliases:

GP145-TrkC|Trk-C|Neurotrophic tyrosine kinase receptor type 3|TrkC tyrosine kinase

Accession Number:

NM_002530

UniProt Number:

Q16288

Gene Name:

NTRK3

Gene ID:

4916

Gene Aliases:

TRKC

Target Species:

Human