Biological Information

Background Information:

Src family kinases, Src, Fyn, and Yes, are expressed in numerous cell types, including neurons and muscle, and their activities are implicated in multiple signaling pathways. YES kinase is believed to play critical roles in tumor growth, angiogenesis, invasion, and dissemination. YES1 (YES) kinase has been implicated in several human cancers, such as advanced colon cancers and endometrial cancer. YES1 kinase inhibitors may be of therapeutic use in the treatment of human cancer. GenBank M15990

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

YES

Protein Aliases:

Proto-oncogene c-Yes|p61-Yes

Accession Number:

NM_005433.3

UniProt Number:

P07947

Gene Name:

YES1

Gene ID:

7525

Gene Aliases:

Yes|c-yes|HsT441

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology