ZAK, active

Background Information:

ZAK is a member of the MAPKKK family of signal transduction molecules and is a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

ZAK

Protein Aliases:

Human cervical cancer suppressor gene 4 protein|HCCS-4|Leucine zipper- and sterile alpha motif-containing kinase|MLK-like mitogen-activated protein triple kinase|Mitogen-activated protein kinase kinase kinase MLT|Mixed lineage kinase-related kinase|MLK-related kinase|MRK|Sterile alpha motif- and leucine zipper-containing kinase AZK

Accession Number:

NM_016653.2

UniProt Number:

Q9NYL2

Gene Name:

MAP3K20

Gene ID:

51776

Gene Aliases:

MLTKalpha|MLTKbeta|ZAK|MLTK|MLK7|MRK

Target Species:

Human